Aminothiophenol Furfural Self-assembled Gold Electrode Sensor for Determination of Dopamine in Pharmaceutical Formulations

Document Type : Research Paper

Abstract

A new Schiff base 2-aminothiophenol furfural self assembled monolayer (SAM) has been fabricated on a bare gold electrode as a novel sensor for determination of dopamine. Electrochemical impedance spectroscopy
was utilized to investigate the properties of the Au 2-aminothiophenol furfural self assembled monolayer
modified electrode (Au ATF SAM-ME) using the [Fe(CN)6]3-/4- redox couple. The electrochemical behavior
of dopamine on the Au ATF SAM-ME was studied by cyclic voltammetry and differential pulse voltammetry,
using phosphate buffer solution as supporting electrolyte. The ascorbic acid has no response on the modified
self-assembly electrode. A calibration curve was obtained for dopamine in a linear range of 2.0 × 10-6 to 1.0 ×
10-4 M. The detection limit for dopamine was found to be 3.0 × 10-7 M. The results indicated that the Au ATF
SAM-ME could be employed for the determination of dopamine in pharmaceutical formulations.

Keywords

• Dopamine
• Ascorbic acid
• Self-assembled monolayer
• Gold electrode

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