A Sensitive Electrochemical Sensor for Determination of Imipramine in Urine Sample Using Carbon Ionic Liquid Electrode Modified With Montomorillonite Nanoclay

Document Type : Research Paper

Authors

• Elham Eslami ¹
• Fatemeh Farjam ²

¹ Department of Chemistry, Kazerun Branch, Islamic Azad University, Kazerun, Iran

² Department of Chemistry, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran

Abstract

We used an effective electrochemical sensor for the determination of imipramine at pH 7.2 using a carbon nanocomposite electrode. The electrode has been designed by incorporation of montmorillonite nanoclay into the carbon ionic liquid electrode. The high sensitivity of 1.714 μA (μM)-1, two linear calibration ranges of 0.1–2 μM and 2-40 μM, and detection limit of 19 nM were achieved. The relative standard deviations (RSDs) were 2.73% (n=7, 2 μM), 2.97% (n=4, 2 μM), respectively. Thus, this modified electrode was further applied to the determination of imipramine in urine sample.

Keywords

• Carbon ionic liquid electrode
• electrochemical sensor
• Imipramine
• Montomorillonite Nanoclay

---

References

[1] R.A. de Toledo, M.C. Santos, K.M. Honorio, A.B.F. da Silva, E.T.G. Cavalheiro, L.H. Mazo, Anal. Lett., 39 (2006) 507.
[2] T.A. Ivandini, B.V. Sarada, C. Terashima, T.N. Rao, D.A. Tryk, H. Ishiguro, Y.Kubota, A. Fujishima, J. Electroanal. Chem., 521 (2002) 117.
[3] X. Xu, G. Zhou, H. Li, Q. Liu, S. Zhang, J. L. Kong, Talanta.,78(2009) 26.
[4] A. Ferancova, E. Korgova, R. Miko, J. Labuda, J. Electroanal.Chem., 492 (2000) 74.
[5] J. Wang, M. Bonakdar, C. Morgan, Anal. Chem., 58(1986) 1024.
[6] I. Biryol, B. Uslu, Z. Kucukyavuz, J. Pharm. Biomed. Anal., 15 (1996) 371.
[7] E. Eslami, F. Farjami, P. Abroomand Azar, M. Saber Tehrani, Electroanalysis., 26 (2014) 424 .
[8] S. Shahrokhian, M. Ghalkhani, Electrochim. Acta., 55 (2010) 3621.
[9] P. Manisankar, C. Vedhi, S. Viswanathan, H. G. Prabu, J.Environ. Sci. Health., B39 (2004) 89.
[10] A.J. Bard, T. Mallouk, Molecular Design of Electrode Surface, Wiley., New York (1992).
[11] Y. Gomez, L. Fernandez, C. Borras, J. Mostany, B. Scharifker , Talanta., 85 (2011) 1357.
[12] Z. Dai, Y. Xiao, X. Yu, Z. Mai, X. Zhao, X. Zou, Biosens. Bioelectron., 24 (2009) 629.
[13] C. Lei, D .Hu, E .Ackerman, Nano Lett., 9 (2009) 655.
[14] V.V. Shumyantseva ,Y.D Ivanov, N. Bistolas, F.W., Scheller , A. I. Archakov, U. Wollenberger, Anal. Chem., 76 (2004) 6046 .
[15] N. Maleki, A. Safavi, F. Tajabadi, Anal. Chem., 78 (2006) 3820.
[16] H. Liu, P. He, Z. Li, C. Sun, L. Shi, Y. Liu, G. Zhu, J. Li, Electrochem. Commun., 7 (2005) 1357.
[17] E. Arkan, R. Saber, Z. Karimi, A. Mostafaie, M. Shamsipur , J. Pharm. Biomed. Anal., 92 (2014)74.
[18] D. Brondani, E. Zappa, I. C. Vieira, C.W. Scheeren, J.Dupont, A. M. J. Barbosa, V. S. Ferreira, Sens. Actuators B., 155 (2011) 331.
[19] H. Sun, J. Porous Mater., 13 (2006) 393.
[20] E. Fisicaro, A. Ghizzo, E. Pelizzetti, G. Viscaradi, P. L. Quagliotto, J. Colloid Interf. Sci., 182 (1996) 549.
[21] B. J. Sanghavi, A. K. Srivastava, Analyst.,138( 2013) 1395 .
[22] N. H. Kim, S. V. Malhotra, M. Xanthos, Micropor. Mesopor. Mater., 96 (2006) 29 .
[23] P. Lozano, E. Garcia-Verdugo, R. Piamtongkam, N. Karbass, T. D. Diego, M. I. Burguete, S. V. Luis, J. L. Iborra, Adv. Synth. Catal., 349 (2007) 1077.
[24] C.H.Lei , J.Q.Deng, Anal .Chem., 68 (1996) 3344.
[25] A. Fitch; R. J.Krzysik,. J. Electroanal. Chem., 379 (1995) 129.
[26] E. S. Smotkin, C. B. Martin, G. A. Rechnitz, Anal. Lett., 24 (1991) 797.
[27] M. H. Mashhadizadeh, E. Afshar